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He is an HIV and TB immunologist focused on studying the immune response to these pathogens in affected tissues, and how this relates to what can be observed from the blood. The research goal is to improve understanding of the immunopathology of TB and HIV, using this information to aid in developing novel therapeutic approaches and diagnostic biomarkers. His research has centered on understanding the mechanisms by which the human immune system recognises the Mycobacterium tuberculosis M.

His work has a strong translational component, asking if both classically and non-classically restricted T cells are associated with infection with M.

The translational significance of this research is centred on informing the development of novel vaccines and diagnostics for childhood TB. Her current research focuses on HIV broadly neutralising antibodies and their interplay with the evolving virus.

Recent studies published in PloS Pathogens, Nature and Nature Medicine have highlighted the role of viral escape in creating new epitopes and immunotypes, thereby driving the development of neutralisation breadth, with implications for HIV vaccine design. Research interest in tuberculosis and in developing and testing point of care diagnostics suitable for the developing world.

More specifically, the reconstitution of the immune response during antiretroviral treatment, in order to identify correlates of protection including immune mechanisms that lead to reduced susceptibility to TB , and pathogenesis such as the Tuberculosis-Associated Immune Reconstitution Inflammatory Syndrome, TB-IRIS ; the biosignature of the TB infection spectrum, from latent infection to active disease; preventing TB infection in HIV infected people more effectively; and the pathogenesis of tuberculous meningitis and pericarditis.

Skip to main content. Sequencing of individual human lymphocyte clones shows that they are highly prone to mutations, with higher burdens in memory cells than in naive cells arising from mutational processes associated with differentiation and tissue residency. Monocytes recruited to skin infection are not involved in bacterial clearance but instead regulate local angiogenesis and healing. Fabrication of a low-dimensional metal halide perovskite superlattice by chemical epitaxy is reported, with a criss-cross two-dimensional network parallel to the substrate, leading to efficient carrier transport in three dimensions.

Copy number variations inferred from spatial transcriptomics data in benign and malignant tissue reveal clonal architecture at the organ-wide level. Spatial and single-cell transcriptomic characterization of microglia in the mouse somatosensory cortex show that the state of these cells is determined by signals from diverse surrounding neurons.

Advanced search. Skip to main content Thank you for visiting nature. Browse Articles. Filter By: Article Type All. Year All. Author Correction 10 Aug Reply to: On yoctosecond science Kilian P. Matters Arising 10 Aug Why low temperatures could help starve tumours of fuel Cold exposure in mice activates brown fat to deny tumours glucose, and the future of extreme heatwaves.

Nature Podcast 10 Aug The nanoscience revolution Breakthroughs in nanotechnology could offer wide-ranging benefits to a host of industries, from agriculture to computing, but getting public buy-in remains key. Nature Index 10 Aug Research Highlight 10 Aug Quantum cascade of correlated phases in trigonally warped bilayer graphene A cascade of gate-tunable correlated insulating and metallic phases is observed in trigonally warped Bernal bilayer graphene at large electric fields.

Article 10 Aug Sufficient conditions for rapid range expansion of a boreal conifer A boreal conifer is advancing northwards into Arctic tundra, with this treeline advance facilitated by climate warming together with winter winds, deeper snow and increased soil nutrient availability.

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Areas of interest span the basic sciences of chemistry, biochemistry and microbiology, through to pharmacology and clinical medicine, in the areas of mycobacterial pathogenesis and TB drug discovery research.

Honorary Professor at UCT. His primary research interests are C-type lectin receptors and their role in homeostasis and immunity, with a particular focus on antifungal immunity. His research interests revolve around investigating immune regulation and dysregulation in the context of HIV infection or exposure. He focuses on Immune ontogeny in HIV exposed infants, placental investigations and pre-term birth, and epithelial immunity in the foreskin.

Her Research Unit is involved with clinical research, epidemiology and operational research, and is a treatment site for HIV infected adults and children. Her research interests include HIV vaccine research, microbicide research and other biomedical and behavioural interventions, and she is an investigator in testing two HIV vaccine regimens in late stage clinical development.

He has been an author on over manuscripts in the field of infectious diseases and has an extensive track record in infectious diseases research and practice covering clinical, laboratory and epidemiological aspects. He is an HIV and TB immunologist focused on studying the immune response to these pathogens in affected tissues, and how this relates to what can be observed from the blood.

The research goal is to improve understanding of the immunopathology of TB and HIV, using this information to aid in developing novel therapeutic approaches and diagnostic biomarkers. His research has centered on understanding the mechanisms by which the human immune system recognises the Mycobacterium tuberculosis M. His work has a strong translational component, asking if both classically and non-classically restricted T cells are associated with infection with M. The translational significance of this research is centred on informing the development of novel vaccines and diagnostics for childhood TB.

Her current research focuses on HIV broadly neutralising antibodies and their interplay with the evolving virus. Recent studies published in PloS Pathogens, Nature and Nature Medicine have highlighted the role of viral escape in creating new epitopes and immunotypes, thereby driving the development of neutralisation breadth, with implications for HIV vaccine design.

Research interest in tuberculosis and in developing and testing point of care diagnostics suitable for the developing world. More specifically, the reconstitution of the immune response during antiretroviral treatment, in order to identify correlates of protection including immune mechanisms that lead to reduced susceptibility to TB , and pathogenesis such as the Tuberculosis-Associated Immune Reconstitution Inflammatory Syndrome, TB-IRIS ; the biosignature of the TB infection spectrum, from latent infection to active disease; preventing TB infection in HIV infected people more effectively; and the pathogenesis of tuberculous meningitis and pericarditis.

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An iron—cobalt—nickel—tantalum—aluminium multicomponent alloy with ferromagnetic matrix and paramagnetic coherent nanoparticles is described, showing high tensile strength and ductility, along with very low coercivity. Sequencing of individual human lymphocyte clones shows that they are highly prone to mutations, with higher burdens in memory cells than in naive cells arising from mutational processes associated with differentiation and tissue residency. Monocytes recruited to skin infection are not involved in bacterial clearance but instead regulate ddesigner angiogenesis and affinity designer mirror free.

Fabrication of a low-dimensional metal halide perovskite superlattice by chemical fere is reported, with a criss-cross two-dimensional network parallel to the substrate, leading to affinity designer mirror free carrier transport in three dimensions.

Copy number variations inferred from spatial transcriptomics data in benign and malignant tissue reveal affinity designer mirror free architecture at the organ-wide level. Spatial and single-cell transcriptomic characterization of microglia in the mouse somatosensory cortex show that the state of these cells is determined by signals from diverse surrounding neurons.

Advanced search. Skip to main content Thank you for visiting nature. Browse Articles. Filter By: Article Type All. Year All. Author Correction 10 Aug Reply to: On yoctosecond science Kilian P.

Matters Arising 10 Aug Why low temperatures could help starve tumours of fuel Cold exposure in mice activates brown fat to deny tumours glucose, and the future of extreme heatwaves. Nature Podcast 10 Aug The nanoscience revolution Breakthroughs in nanotechnology could offer dfsigner benefits здесь a host of industries, from agriculture to computing, but getting public buy-in remains key.

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A mechanically strong and ductile soft magnet with extremely low coercivity An iron—cobalt—nickel—tantalum—aluminium multicomponent alloy with ferromagnetic matrix and paramagnetic coherent nanoparticles is described, showing high tensile strength and ductility, along with very low coercivity. Sketchup pro 2018 pdf free download mutational landscapes in human lymphocytes Sequencing of individual human lymphocyte clones shows that they are highly prone to mutations, with higher affinity designer mirror free in memory cells than in naive cells arising from mutational processes associated with differentiation and tissue residency.

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